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Hem psikolojik olarak hem de içerisinde bulunan maddelerden dolayı bağımlılık yapabilen Viagra, doktor tavsiyesi olmadan kullanılması sakıncalıdır.PDE3 is associated in control of cardiac contractility. Sildenafil is only about 10-fold as powerful for PDE5 when compared to PDE6, an enzyme found in the retina that is associated with the p